Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Incyte Corp 16,972,968 8.93 -791,000 6/17/20
Oracle Investment Management, Inc. 13,134,900 6.91 148,400 9/30/20
RTW Investments L.P. 12,864,677 6.77 -- 9/30/20
BlackRock Institutional Trust Company, N.A. 11,093,418 5.83 969,785 9/30/20
The Vanguard Group, Inc. 8,547,912 4.50 752,651 9/30/20
Cormorant Asset Management, LP 8,500,000 4.47 -2,500,000 9/30/20
Invus Public Equities Advisors, LLC 6,900,000 3.63 4,050,000 9/30/20
State Street Global Advisors (US) 6,725,238 3.54 104,509 9/30/20
Boxer Capital, L.L.C. 4,000,000 2.10 -- 9/30/20
Millennium Management LLC 2,393,799 1.26 54,650 9/30/20
Geode Capital Management, L.L.C. 2,244,778 1.18 198,361 9/30/20
Northern Trust Investments, Inc. 1,602,385 0.84 327,578 9/30/20
Kelley (Brad M) 1,591,039 0.84 -- 4/24/20
First Manhattan Company 1,391,100 0.73 397,000 9/30/20
BlackRock Financial Management, Inc. 1,208,181 0.64 87,116 9/30/20
T. Rowe Price Associates, Inc. 1,198,313 0.63 -670,199 9/30/20
Charles Schwab Investment Management, Inc. 1,054,929 0.55 68,100 9/30/20
Two Sigma Investments, LP 951,367 0.50 142,781 9/30/20
Ikarian Capital LLC 950,000 0.50 950,000 9/30/20
Wells Fargo Advisors 863,902 0.45 13,985 9/30/20
Assenagon Asset Management S.A. 809,252 0.43 809,252 9/30/20
Trellus Management Company, LLC 750,000 0.39 440,000 9/30/20
PanAgora Asset Management Inc. 719,871 0.38 -19,391 9/30/20
BlackRock Investment Management, LLC 696,260 0.37 6,117 9/30/20
FundLogic SAS 646,755 0.34 646,755 9/30/20
Goldman Sachs & Company, Inc. 622,608 0.33 401 9/30/20
Armen (Garo H Ph.D.) 573,514 0.30 7,918 11/20/20
Nuveen LLC 564,019 0.30 53,285 9/30/20
CAPTRUST Financial Advisors 496,412 0.26 20,000 9/30/20
BNY Mellon Asset Management 423,997 0.22 40,439 9/30/20
Acadian Asset Management LLC 379,919 0.20 -402,549 9/30/20
Los Angeles Capital Management And Equity Research, Inc. 370,884 0.20 -105,047 9/30/20
California Public Employees' Retirement System 343,385 0.18 37,134 9/30/20
BlackRock Investment Management (UK) Ltd. 318,419 0.17 -- 9/30/20
State of Wisconsin Investment Board 301,700 0.16 136,600 9/30/20
Saling Wealth Advisors 296,003 0.16 -35,000 9/30/20
Schweizerische Nationalbank 288,600 0.15 43,300 9/30/20
Verition Fund Management LLC 282,195 0.15 282,195 9/30/20
Citadel Advisors LLC 276,802 0.15 -630,433 9/30/20
D. E. Shaw & Co., L.P. 266,883 0.14 -371,982 9/30/20
Principal Global Investors (Equity) 263,028 0.14 98,984 9/30/20
PDT Partners, LLC 253,600 0.13 253,600 9/30/20
California State Teachers Retirement System 229,594 0.12 20,879 9/30/20
Morgan Stanley Smith Barney LLC 220,050 0.12 13,146 9/30/20
Susquehanna International Group, LLP 209,113 0.11 170,685 9/30/20

* Insider values reflect direct beneficial ownership.

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