Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Incyte Corp 14,062,227 7.40 -2,910,741 12/31/20
RTW Investments L.P. 12,864,677 6.77 -- 12/31/20
BlackRock Institutional Trust Company, N.A. 12,000,269 5.86 -52,918 3/31/21
Oracle Investment Management, Inc. 11,852,372 6.23 -1,282,528 12/31/20
Gilead Sciences Inc 11,111,111 5.43 11,111,111 4/23/21
State Street Global Advisors (US) 10,300,531 5.42 3,575,293 12/31/20
The Vanguard Group, Inc. 9,522,188 5.01 974,276 12/31/20
Cormorant Asset Management, LP 7,000,000 3.68 -1,500,000 12/31/20
Invus Public Equities Advisors, LLC 6,900,000 3.63 -- 12/31/20
Millennium Management LLC 4,393,598 2.31 1,999,799 12/31/20
Boxer Capital, L.L.C. 4,000,000 2.10 -- 12/31/20
Geode Capital Management, L.L.C. 2,457,595 1.29 212,817 12/31/20
First Manhattan Company 2,376,293 1.25 985,193 12/31/20
Kelley (Brad M) 1,591,039 0.78 -- 4/23/21
Northern Trust Investments, Inc. 1,572,579 0.83 -29,806 12/31/20
Armen (Garo H Ph.D.) 1,421,163 0.69 815,018 4/23/21
Two Sigma Investments, LP 1,345,176 0.71 393,809 12/31/20
D. E. Shaw & Co., L.P. 1,277,267 0.67 1,010,384 12/31/20
BlackRock Financial Management, Inc. 1,179,987 0.53 -78,705 3/31/21
Buell (Jennifer) 1,092,327 0.53 1,056,671 4/23/21
Charles Schwab Investment Management, Inc. 1,036,876 0.55 -18,053 12/31/20
Ikarian Capital LLC 950,000 0.50 -- 12/31/20
Wells Fargo Advisors 829,764 0.44 -34,138 12/31/20
Renaissance Technologies LLC 763,515 0.40 592,795 12/31/20
PanAgora Asset Management Inc. 726,812 0.38 6,941 12/31/20
Rafferty Asset Management LLC 651,498 0.29 542,399 3/31/21
Goldman Sachs & Company, Inc. 639,582 0.34 16,974 12/31/20
BlackRock Investment Management, LLC 605,020 0.30 -77,670 3/31/21
Los Angeles Capital Management And Equity Research, Inc. 553,744 0.27 -103,215 3/31/21
Nuveen LLC 546,742 0.29 -17,277 12/31/20
CAPTRUST Financial Advisors 511,992 0.27 15,580 12/31/20
BNY Mellon Asset Management 432,813 0.23 8,816 12/31/20
Morgan Stanley & Co. LLC 359,320 0.19 301,570 12/31/20
SEI Investments Management Corporation 355,458 0.17 355,458 3/31/21
Russell Investments Trust Company 347,057 0.18 201,611 12/31/20
Schweizerische Nationalbank 325,900 0.16 14,800 3/31/21
California Public Employees' Retirement System 308,500 0.16 -34,885 12/31/20
Saling Wealth Advisors 306,003 0.15 10,000 3/31/21
Susquehanna International Group, LLP 296,748 0.16 87,635 12/31/20
PDT Partners, LLC 253,600 0.13 -- 12/31/20
Morgan Stanley Smith Barney LLC 246,425 0.13 26,375 12/31/20
Squarepoint Capital LLP 241,122 0.13 98,808 12/31/20
California State Teachers Retirement System 237,847 0.13 8,253 12/31/20
Credit Suisse Securities (USA) LLC 233,620 0.12 82,235 12/31/20
State of Wisconsin Investment Board 231,200 0.12 -70,500 12/31/20

* Insider values reflect direct beneficial ownership.

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