Institutional Ownership
Top Holders
| Holder | Shares Held | % O/S | Share Change | Filing Date |
|---|---|---|---|---|
| The Vanguard Group, Inc. | 14,935,458 | 5.82 | 1,032,053 | 9/30/21 |
| Incyte Corp | 14,062,227 | 5.48 | -2,910,741 | 12/31/20 |
| BlackRock Institutional Trust Company, N.A. | 13,528,044 | 5.27 | 397,469 | 9/30/21 |
| State Street Global Advisors (US) | 12,313,018 | 4.79 | 1,296,184 | 9/30/21 |
| Gilead Sciences Inc | 11,111,111 | 4.33 | 11,111,111 | 4/23/21 |
| Oracle Investment Management, Inc. | 9,437,334 | 3.67 | 263,752 | 9/30/21 |
| RTW Investments L.P. | 9,074,438 | 3.53 | -2,362,800 | 9/30/21 |
| Millennium Management LLC | 5,791,454 | 2.26 | 154,875 | 9/30/21 |
| Invus Public Equities Advisors, LLC | 5,500,000 | 2.14 | -500,000 | 9/30/21 |
| Cormorant Asset Management, LP | 4,807,557 | 1.87 | -- | 9/30/21 |
| Geode Capital Management, L.L.C. | 3,614,361 | 1.41 | 228,007 | 9/30/21 |
| D. E. Shaw & Co., L.P. | 3,055,649 | 1.19 | 1,899,244 | 9/30/21 |
| Two Sigma Investments, LP | 2,655,010 | 1.03 | 1,663,621 | 9/30/21 |
| Sofinnova Investments, Inc | 2,344,410 | 0.91 | -425,490 | 9/30/21 |
| Renaissance Technologies LLC | 1,989,615 | 0.77 | 1,919,600 | 9/30/21 |
| Northern Trust Investments, Inc. | 1,891,816 | 0.74 | 75,343 | 9/30/21 |
| BlackRock Financial Management, Inc. | 1,884,080 | 0.73 | 114,011 | 9/30/21 |
| Susquehanna International Group, LLP | 1,874,831 | 0.73 | 1,046,640 | 9/30/21 |
| Nuveen LLC | 1,777,960 | 0.69 | 1,132,347 | 9/30/21 |
| Kelley (Brad M) | 1,591,039 | 0.62 | -- | 4/23/21 |
| Charles Schwab Investment Management, Inc. | 1,483,549 | 0.58 | 183,603 | 9/30/21 |
| Armen (Garo H.) | 1,475,742 | 0.57 | 37,071 | 9/13/21 |
| Voloridge Investment Management, LLC | 1,105,172 | 0.43 | 1,051,990 | 9/30/21 |
| Buell (Jennifer) | 1,102,924 | 0.43 | 10,597 | 6/30/21 |
| Goldman Sachs & Company, Inc. | 1,012,542 | 0.39 | 283,624 | 9/30/21 |
| Morgan Stanley & Co. LLC | 956,743 | 0.37 | -97,206 | 9/30/21 |
| Connor, Clark & Lunn Investment Management Ltd. | 934,007 | 0.36 | 934,007 | 9/30/21 |
| PanAgora Asset Management Inc. | 927,097 | 0.36 | 165,751 | 9/30/21 |
| Wells Fargo Advisors | 862,801 | 0.34 | -2,355 | 9/30/21 |
| Medical Strategy GmbH | 833,176 | 0.32 | -170,824 | 9/30/21 |
| Jess S. Morgan & Company, Inc | 786,533 | 0.31 | 5,943 | 9/30/21 |
| Citadel Advisors LLC | 702,697 | 0.27 | 287,523 | 9/30/21 |
| BlackRock Investment Management, LLC | 657,840 | 0.26 | -58,109 | 9/30/21 |
| Federated Hermes MDTA LLC | 629,787 | 0.25 | 576,431 | 9/30/21 |
| SELECTRA Management Company S.A. | 580,000 | 0.23 | 580,000 | 6/30/21 |
| CAPTRUST Financial Advisors | 540,992 | 0.21 | 7,372 | 9/30/21 |
| Principal Global Investors (Equity) | 492,794 | 0.19 | 2,163 | 9/30/21 |
| BNY Mellon Asset Management | 487,625 | 0.19 | 27,037 | 9/30/21 |
| Rafferty Asset Management LLC | 479,393 | 0.19 | 59,731 | 9/30/21 |
| Tudor Investment Corporation | 468,146 | 0.18 | 451,309 | 9/30/21 |
| Schweizerische Nationalbank | 393,200 | 0.15 | 36,900 | 9/30/21 |
| PDT Partners, LLC | 354,900 | 0.14 | 92,470 | 9/30/21 |
| Cubist Systematic Strategies, LLC | 351,863 | 0.14 | -57,666 | 9/30/21 |
| Citi Investment Research (US) | 323,700 | 0.13 | -436,909 | 9/30/21 |
| Hightower Advisors, LLC | 310,601 | 0.12 | -3,691 | 9/30/21 |
* Insider values reflect direct beneficial ownership.
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