Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Incyte Corp 14,062,227 6.03 -2,910,741 12/31/20
The Vanguard Group, Inc. 13,903,405 5.96 2,109,183 6/30/21
BlackRock Institutional Trust Company, N.A. 13,130,575 5.63 1,130,306 6/30/21
RTW Investments L.P. 11,437,238 4.91 -2,340,006 6/30/21
Gilead Sciences Inc 11,111,111 4.77 11,111,111 4/23/21
State Street Global Advisors (US) 11,016,834 4.73 -1,660,586 6/30/21
Oracle Investment Management, Inc. 9,173,582 3.94 -200,000 6/30/21
Invus Public Equities Advisors, LLC 6,000,000 2.57 -- 6/30/21
Millennium Management LLC 5,636,579 2.42 1,549,205 6/30/21
Cormorant Asset Management, LP 4,807,557 2.06 -2,942,443 6/30/21
Boxer Capital, L.L.C. 4,000,000 1.72 -- 6/30/21
Geode Capital Management, L.L.C. 3,386,354 1.45 583,004 6/30/21
Sofinnova Investments, Inc 2,769,900 1.19 -708,301 6/30/21
Great Lakes Advisors, LLC 2,484,757 1.07 2,484,757 6/30/21
Point72 Asset Management, L.P. 2,045,800 0.88 -588,000 6/30/21
Northern Trust Investments, Inc. 1,816,473 0.78 300,059 6/30/21
BlackRock Financial Management, Inc. 1,770,069 0.76 590,082 6/30/21
Kelley (Brad M) 1,591,039 0.68 -- 4/23/21
Armen (Garo H.) 1,475,742 0.63 37,071 9/13/21
Charles Schwab Investment Management, Inc. 1,299,946 0.56 243,017 6/30/21
D. E. Shaw & Co., L.P. 1,156,405 0.50 -85,864 6/30/21
Buell (Jennifer) 1,102,924 0.47 10,597 6/30/21
Morgan Stanley & Co. LLC 1,053,949 0.45 1,034,777 6/30/21
Medical Strategy GmbH 1,004,000 0.43 1,004,000 5/31/21
Two Sigma Investments, LP 991,389 0.43 619,665 6/30/21
Wells Fargo Advisors 865,156 0.37 57,150 6/30/21
Susquehanna International Group, LLP 828,191 0.36 406,238 6/30/21
PanAgora Asset Management Inc. 761,346 0.33 22,727 6/30/21
Citi Investment Research (US) 760,609 0.33 -46,676 6/30/21
Goldman Sachs & Company, Inc. 728,918 0.31 -91,339 6/30/21
BlackRock Investment Management, LLC 715,949 0.31 110,929 6/30/21
Nuveen LLC 645,613 0.28 -255,980 6/30/21
SELECTRA Management Company S.A. 580,000 0.25 580,000 6/30/21
CAPTRUST Financial Advisors 533,620 0.23 1,628 6/30/21
Principal Global Investors (Equity) 490,631 0.21 258,511 6/30/21
BNY Mellon Asset Management 460,588 0.20 39,587 6/30/21
Rafferty Asset Management LLC 419,662 0.18 -231,836 6/30/21
Citadel Advisors LLC 415,174 0.18 273,596 6/30/21
Cubist Systematic Strategies, LLC 409,529 0.18 358,547 6/30/21
Squarepoint Capital LLP 402,992 0.17 149,762 6/30/21
Schweizerische Nationalbank 356,300 0.15 30,400 6/30/21
Hightower Advisors, LLC 314,292 0.13 5,696 6/30/21
Los Angeles Capital Management And Equity Research, Inc. 306,871 0.13 -246,873 6/30/21
Saling Wealth Advisors 306,123 0.13 120 6/30/21
Gyon Technologies Capital Management, LP 281,333 0.12 239,625 6/30/21

* Insider values reflect direct beneficial ownership.

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