Institutional Ownership

Top Holders

Holder	Shares Held	% O/S	Share Change	Filing Date
Incyte Corp	14,062,227	6.03	-2,910,741	12/31/20
The Vanguard Group, Inc.	13,903,405	5.96	2,109,183	6/30/21
BlackRock Institutional Trust Company, N.A.	13,130,575	5.63	1,130,306	6/30/21
RTW Investments L.P.	11,437,238	4.91	-2,340,006	6/30/21
Gilead Sciences Inc	11,111,111	4.77	11,111,111	4/23/21
State Street Global Advisors (US)	11,016,834	4.73	-1,660,586	6/30/21
Oracle Investment Management, Inc.	9,173,582	3.94	-200,000	6/30/21
Invus Public Equities Advisors, LLC	6,000,000	2.57	--	6/30/21
Millennium Management LLC	5,636,579	2.42	1,549,205	6/30/21
Cormorant Asset Management, LP	4,807,557	2.06	-2,942,443	6/30/21
Boxer Capital, L.L.C.	4,000,000	1.72	--	6/30/21
Geode Capital Management, L.L.C.	3,386,354	1.45	583,004	6/30/21
Sofinnova Investments, Inc	2,769,900	1.19	-708,301	6/30/21
Great Lakes Advisors, LLC	2,484,757	1.07	2,484,757	6/30/21
Point72 Asset Management, L.P.	2,045,800	0.88	-588,000	6/30/21
Northern Trust Investments, Inc.	1,816,473	0.78	300,059	6/30/21
BlackRock Financial Management, Inc.	1,770,069	0.76	590,082	6/30/21
Kelley (Brad M)	1,591,039	0.68	--	4/23/21
Armen (Garo H.)	1,475,742	0.63	37,071	9/13/21
Charles Schwab Investment Management, Inc.	1,299,946	0.56	243,017	6/30/21
D. E. Shaw & Co., L.P.	1,156,405	0.50	-85,864	6/30/21
Buell (Jennifer)	1,102,924	0.47	10,597	6/30/21
Morgan Stanley & Co. LLC	1,053,949	0.45	1,034,777	6/30/21
Medical Strategy GmbH	1,004,000	0.43	1,004,000	5/31/21
Two Sigma Investments, LP	991,389	0.43	619,665	6/30/21
Wells Fargo Advisors	865,156	0.37	57,150	6/30/21
Susquehanna International Group, LLP	828,191	0.36	406,238	6/30/21
PanAgora Asset Management Inc.	761,346	0.33	22,727	6/30/21
Citi Investment Research (US)	760,609	0.33	-46,676	6/30/21
Goldman Sachs & Company, Inc.	728,918	0.31	-91,339	6/30/21
BlackRock Investment Management, LLC	715,949	0.31	110,929	6/30/21
Nuveen LLC	645,613	0.28	-255,980	6/30/21
SELECTRA Management Company S.A.	580,000	0.25	580,000	6/30/21
CAPTRUST Financial Advisors	533,620	0.23	1,628	6/30/21
Principal Global Investors (Equity)	490,631	0.21	258,511	6/30/21
BNY Mellon Asset Management	460,588	0.20	39,587	6/30/21
Rafferty Asset Management LLC	419,662	0.18	-231,836	6/30/21
Citadel Advisors LLC	415,174	0.18	273,596	6/30/21
Cubist Systematic Strategies, LLC	409,529	0.18	358,547	6/30/21
Squarepoint Capital LLP	402,992	0.17	149,762	6/30/21
Schweizerische Nationalbank	356,300	0.15	30,400	6/30/21
Hightower Advisors, LLC	314,292	0.13	5,696	6/30/21
Los Angeles Capital Management And Equity Research, Inc.	306,871	0.13	-246,873	6/30/21
Saling Wealth Advisors	306,123	0.13	120	6/30/21
Gyon Technologies Capital Management, LP	281,333	0.12	239,625	6/30/21

* Insider values reflect direct beneficial ownership.