Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 18,402,409 6.81 767,856 3/31/22
State Street Global Advisors (US) 17,758,624 6.57 -3,412,226 3/31/22
BlackRock Institutional Trust Company, N.A. 14,770,596 5.47 284,319 3/31/22
Deep Track Capital LP 13,998,491 5.18 13,998,491 3/31/22
Incyte Corp 12,070,195 4.47 -1,992,032 12/31/21
Gilead Sciences Inc 11,111,111 4.11 -- 12/31/21
Oracle Investment Management, Inc. 8,706,132 3.22 -400,000 3/31/22
Millennium Management LLC 5,732,026 2.12 810,497 3/31/22
Invus Public Equities Advisors, LLC 5,500,000 2.04 -1,000,000 3/31/22
Renaissance Technologies LLC 4,922,715 1.82 2,143,000 3/31/22
Geode Capital Management, L.L.C. 3,853,817 1.43 -245,935 3/31/22
RTW Investments L.P. 3,582,481 1.33 -2,285,834 3/31/22
D. E. Shaw & Co., L.P. 3,008,670 1.11 -1,997,304 3/31/22
Nuveen LLC 2,567,682 0.95 -15,447 3/31/22
Northern Trust Investments, Inc. 1,942,645 0.72 -77,808 3/31/22
BlackRock Financial Management, Inc. 1,910,140 0.71 9,155 3/31/22
Armen (Garo H.) 1,712,756 0.63 3 4/11/22
Charles Schwab Investment Management, Inc. 1,692,344 0.63 64,856 3/31/22
Kelley (Brad M) 1,591,039 0.59 -- 4/11/22
Goldman Sachs & Company, Inc. 1,303,067 0.48 -1,279,271 3/31/22
Jess S. Morgan & Company, Inc 1,278,580 0.47 459,097 3/31/22
Morgan Stanley & Co. LLC 1,217,796 0.45 400,960 3/31/22
Rafferty Asset Management LLC 1,167,265 0.43 -470,373 3/31/22
Susquehanna International Group, LLP 1,167,116 0.43 -985,873 3/31/22
Wells Fargo Advisors 1,043,658 0.39 199,116 3/31/22
Two Sigma Investments, LP 763,324 0.28 -439,785 3/31/22
PanAgora Asset Management Inc. 746,764 0.28 456,594 3/31/22
BlackRock Investment Management, LLC 668,959 0.25 -5,324 3/31/22
Pinz Capital Management, LP 609,000 0.23 609,000 3/31/22
SELECTRA Management Company S.A. 580,000 0.21 580,000 6/30/21
Saling Wealth Advisors 551,265 0.20 95,142 3/31/22
CAPTRUST Financial Advisors 547,846 0.20 5,154 3/31/22
Putnam Investment Management, L.L.C. 539,680 0.20 -40,186 3/31/22
Wellington Management Company, LLP 525,157 0.19 3,220 3/31/22
AQR Capital Management, LLC 521,018 0.19 -195,588 3/31/22
ExodusPoint Capital Management, LP 513,775 0.19 19,793 3/31/22
BNY Mellon Asset Management 501,444 0.19 7,415 3/31/22
Citadel Advisors LLC 498,286 0.18 87,351 3/31/22
Schweizerische Nationalbank 485,800 0.18 75,500 3/31/22
UBS O'Connor LLC 434,000 0.16 434,000 3/31/22
Key Client Fiduciary Advisors, LLC 424,685 0.16 82,400 3/31/22
Qube Research & Technologies Ltd 397,413 0.15 385,029 3/31/22
HRT Financial LP 384,204 0.14 384,204 3/31/22
ClariVest Asset Management LLC 370,749 0.14 146,349 3/31/22
Hightower Advisors, LLC 366,971 0.14 801 3/31/22

* Insider values reflect direct beneficial ownership.

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