Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
The Vanguard Group, Inc. 14,935,458 5.82 1,032,053 9/30/21
Incyte Corp 14,062,227 5.48 -2,910,741 12/31/20
BlackRock Institutional Trust Company, N.A. 13,528,044 5.27 397,469 9/30/21
State Street Global Advisors (US) 12,313,018 4.79 1,296,184 9/30/21
Gilead Sciences Inc 11,111,111 4.33 11,111,111 4/23/21
Oracle Investment Management, Inc. 9,437,334 3.67 263,752 9/30/21
RTW Investments L.P. 9,074,438 3.53 -2,362,800 9/30/21
Millennium Management LLC 5,791,454 2.26 154,875 9/30/21
Invus Public Equities Advisors, LLC 5,500,000 2.14 -500,000 9/30/21
Cormorant Asset Management, LP 4,807,557 1.87 -- 9/30/21
Geode Capital Management, L.L.C. 3,614,361 1.41 228,007 9/30/21
D. E. Shaw & Co., L.P. 3,055,649 1.19 1,899,244 9/30/21
Two Sigma Investments, LP 2,655,010 1.03 1,663,621 9/30/21
Sofinnova Investments, Inc 2,344,410 0.91 -425,490 9/30/21
Renaissance Technologies LLC 1,989,615 0.77 1,919,600 9/30/21
Northern Trust Investments, Inc. 1,891,816 0.74 75,343 9/30/21
BlackRock Financial Management, Inc. 1,884,080 0.73 114,011 9/30/21
Susquehanna International Group, LLP 1,874,831 0.73 1,046,640 9/30/21
Nuveen LLC 1,777,960 0.69 1,132,347 9/30/21
Kelley (Brad M) 1,591,039 0.62 -- 4/23/21
Charles Schwab Investment Management, Inc. 1,483,549 0.58 183,603 9/30/21
Armen (Garo H.) 1,475,742 0.57 37,071 9/13/21
Voloridge Investment Management, LLC 1,105,172 0.43 1,051,990 9/30/21
Buell (Jennifer) 1,102,924 0.43 10,597 6/30/21
Goldman Sachs & Company, Inc. 1,012,542 0.39 283,624 9/30/21
Medical Strategy GmbH 1,004,000 0.39 -- 6/30/21
Morgan Stanley & Co. LLC 956,743 0.37 -97,206 9/30/21
Connor, Clark & Lunn Investment Management Ltd. 934,007 0.36 934,007 9/30/21
PanAgora Asset Management Inc. 927,097 0.36 165,751 9/30/21
Wells Fargo Advisors 862,801 0.34 -2,355 9/30/21
Jess S. Morgan & Company, Inc 786,533 0.31 5,943 9/30/21
Citadel Advisors LLC 702,697 0.27 287,523 9/30/21
BlackRock Investment Management, LLC 657,840 0.26 -58,109 9/30/21
Federated Hermes MDTA LLC 629,787 0.25 576,431 9/30/21
SELECTRA Management Company S.A. 580,000 0.23 580,000 6/30/21
CAPTRUST Financial Advisors 540,992 0.21 7,372 9/30/21
Principal Global Investors (Equity) 492,794 0.19 2,163 9/30/21
BNY Mellon Asset Management 487,625 0.19 27,037 9/30/21
Rafferty Asset Management LLC 479,393 0.19 59,731 9/30/21
Tudor Investment Corporation 468,146 0.18 451,309 9/30/21
Schweizerische Nationalbank 393,200 0.15 36,900 9/30/21
PDT Partners, LLC 354,900 0.14 92,470 9/30/21
Cubist Systematic Strategies, LLC 351,863 0.14 -57,666 9/30/21
Citi Investment Research (US) 323,700 0.13 -436,909 9/30/21
Hightower Advisors, LLC 310,601 0.12 -3,691 9/30/21

* Insider values reflect direct beneficial ownership.

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