Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Incyte Corp 16,972,968 9.25 -791,000 6/17/20
Oracle Investment Management, Inc. 12,986,500 7.08 6,264,040 7/22/20
RTW Investments L.P. 12,864,677 7.01 -231,948 6/30/20
Gilead Sciences Inc 11,111,111 6.06 11,111,111 1/23/19
Cormorant Asset Management, LP 11,000,000 6.00 -1,174,486 6/30/20
BlackRock Institutional Trust Company, N.A. 10,123,633 5.52 2,057,185 6/30/20
The Vanguard Group, Inc. 7,795,261 4.25 1,918,471 6/30/20
State Street Global Advisors (US) 6,620,729 3.61 2,752,124 6/30/20
Boxer Capital, L.L.C. 4,000,000 2.18 -- 6/30/20
Invus Public Equities Advisors, LLC 2,850,000 1.55 350,000 6/30/20
Millennium Management LLC 2,339,149 1.28 2,339,149 6/30/20
Geode Capital Management, L.L.C. 2,046,417 1.12 483,798 6/30/20
T. Rowe Price Associates, Inc. 1,868,512 1.02 1,799,308 6/30/20
Kelley (Brad M) 1,591,039 0.87 -- 4/24/20
Northern Trust Investments, Inc. 1,274,807 0.69 51,017 6/30/20
BlackRock Financial Management, Inc. 1,121,065 0.61 89,502 6/30/20
First Manhattan Company 994,100 0.54 994,100 6/30/20
Charles Schwab Investment Management, Inc. 986,829 0.54 268,923 6/30/20
Acuta Capital Partners, LLC 932,500 0.51 932,500 6/30/20
Citadel Advisors LLC 907,235 0.49 553,460 6/30/20
Wells Fargo Advisors 849,917 0.46 34,259 6/30/20
Two Sigma Investments, LP 808,586 0.44 -89,788 6/30/20
Acadian Asset Management LLC 782,468 0.43 782,468 6/30/20
PanAgora Asset Management Inc. 739,262 0.40 86,771 6/30/20
BlackRock Investment Management, LLC 690,143 0.38 157,547 6/30/20
D. E. Shaw & Co., L.P. 638,865 0.35 -1,048,915 6/30/20
Goldman Sachs & Company, Inc. 622,207 0.34 45,103 6/30/20
Armen (Garo H Ph.D.) 554,772 0.30 2,962 9/11/20
Nuveen LLC 510,734 0.28 -14,039 6/30/20
CAPTRUST Financial Advisors 476,412 0.26 -- 6/30/20
Los Angeles Capital Management And Equity Research, Inc. 475,931 0.26 473,378 6/30/20
BNY Mellon Asset Management 383,558 0.21 60,989 6/30/20
Saling Wealth Advisors 331,003 0.18 -8,650 6/30/20
BlackRock Investment Management (UK) Ltd. 318,419 0.17 -97,647 6/30/20
Trellus Management Company, LLC 310,000 0.17 210,000 6/30/20
California Public Employees' Retirement System 306,251 0.17 66,810 6/30/20
Deutsche Asset Management Americas 248,104 0.14 248,104 6/30/20
Schweizerische Nationalbank 245,300 0.13 21,800 6/30/20
Cadence Capital Management, LLC 228,834 0.12 9,606 6/30/20
Morgan Stanley & Co. LLC 218,212 0.12 71,420 6/30/20
Credit Suisse Securities (USA) LLC 212,034 0.12 160,652 6/30/20
Wells Fargo Bank, N.A. 211,414 0.12 59,765 6/30/20
California State Teachers Retirement System 208,715 0.11 44,248 6/30/20
Morgan Stanley Smith Barney LLC 206,904 0.11 3,558 6/30/20
Ingalls & Snyder LLC (Asset Management) 200,000 0.11 -- 6/30/20

* Insider values reflect direct beneficial ownership.

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