Institutional Ownership
Top Holders
| Holder | Shares Held | % O/S | Share Change | Filing Date |
|---|---|---|---|---|
| Incyte Corp | 14,062,227 | 6.32 | -2,910,741 | 12/31/20 |
| RTW Investments L.P. | 13,777,244 | 6.19 | 912,567 | 3/31/21 |
| State Street Global Advisors (US) | 12,677,420 | 5.70 | 2,376,889 | 3/31/21 |
| BlackRock Institutional Trust Company, N.A. | 12,000,269 | 5.39 | -52,918 | 3/31/21 |
| The Vanguard Group, Inc. | 11,794,222 | 5.30 | 2,272,034 | 3/31/21 |
| Gilead Sciences Inc | 11,111,111 | 5.00 | 11,111,111 | 4/23/21 |
| Oracle Investment Management, Inc. | 9,373,582 | 4.21 | -2,478,790 | 3/31/21 |
| Cormorant Asset Management, LP | 7,750,000 | 3.48 | 750,000 | 3/31/21 |
| Invus Public Equities Advisors, LLC | 6,000,000 | 2.70 | -900,000 | 3/31/21 |
| Millennium Management LLC | 4,087,374 | 1.84 | -306,224 | 3/31/21 |
| Boxer Capital, L.L.C. | 4,000,000 | 1.80 | -- | 3/31/21 |
| Sofinnova Investments, Inc | 3,478,201 | 1.56 | 3,478,201 | 3/31/21 |
| Geode Capital Management, L.L.C. | 2,803,350 | 1.26 | 345,755 | 3/31/21 |
| Point72 Asset Management, L.P. | 2,633,800 | 1.18 | 2,633,800 | 3/31/21 |
| First Manhattan Company | 2,376,393 | 1.07 | 100 | 3/31/21 |
| Kelley (Brad M) | 1,591,039 | 0.72 | -- | 4/23/21 |
| Northern Trust Investments, Inc. | 1,516,414 | 0.68 | -56,165 | 3/31/21 |
| Armen (Garo H Ph.D.) | 1,433,180 | 0.64 | 3,670 | 6/4/21 |
| D. E. Shaw & Co., L.P. | 1,242,269 | 0.56 | -34,998 | 3/31/21 |
| BlackRock Financial Management, Inc. | 1,179,987 | 0.53 | -78,705 | 3/31/21 |
| Buell (Jennifer) | 1,092,327 | 0.49 | 1,056,671 | 4/23/21 |
| Charles Schwab Investment Management, Inc. | 1,056,929 | 0.48 | 20,053 | 3/31/21 |
| Nuveen LLC | 901,593 | 0.41 | 354,851 | 3/31/21 |
| Goldman Sachs & Company, Inc. | 820,257 | 0.37 | 180,675 | 3/31/21 |
| Wells Fargo Advisors | 808,006 | 0.36 | -21,758 | 3/31/21 |
| Citi Investment Research (US) | 807,285 | 0.36 | 769,922 | 3/31/21 |
| PanAgora Asset Management Inc. | 738,619 | 0.33 | 11,807 | 3/31/21 |
| Ikarian Capital LLC | 678,843 | 0.31 | -271,157 | 3/31/21 |
| Rafferty Asset Management LLC | 651,498 | 0.29 | 542,399 | 3/31/21 |
| BlackRock Investment Management, LLC | 605,020 | 0.27 | -77,670 | 3/31/21 |
| Renaissance Technologies LLC | 590,215 | 0.27 | -173,300 | 3/31/21 |
| Los Angeles Capital Management And Equity Research, Inc. | 553,744 | 0.25 | -103,215 | 3/31/21 |
| CAPTRUST Financial Advisors | 531,992 | 0.24 | 20,000 | 3/31/21 |
| Susquehanna International Group, LLP | 421,953 | 0.19 | 125,205 | 3/31/21 |
| BNY Mellon Asset Management | 421,001 | 0.19 | -11,812 | 3/31/21 |
| Two Sigma Investments, LP | 371,724 | 0.17 | -973,452 | 3/31/21 |
| Schweizerische Nationalbank | 325,900 | 0.15 | 14,800 | 3/31/21 |
| UBS Financial Services, Inc. | 313,644 | 0.14 | 302,396 | 3/31/21 |
| Hightower Advisors, LLC | 308,596 | 0.14 | 117,121 | 3/31/21 |
| California Public Employees' Retirement System | 308,500 | 0.14 | -- | 3/31/21 |
| Russell Investments Trust Company | 307,431 | 0.14 | -39,626 | 3/31/21 |
| Saling Wealth Advisors | 306,003 | 0.14 | 10,000 | 3/31/21 |
| Jane Street Capital, L.L.C. | 304,697 | 0.14 | 262,305 | 3/31/21 |
| SEI Investments Management Corporation | 281,998 | 0.13 | 146,378 | 4/30/21 |
| Morgan Stanley Smith Barney LLC | 271,362 | 0.12 | 24,937 | 3/31/21 |
* Insider values reflect direct beneficial ownership.
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