Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
Incyte Corp 14,062,227 6.32 -2,910,741 12/31/20
RTW Investments L.P. 13,777,244 6.19 912,567 3/31/21
State Street Global Advisors (US) 12,677,420 5.70 2,376,889 3/31/21
BlackRock Institutional Trust Company, N.A. 12,000,269 5.39 -52,918 3/31/21
The Vanguard Group, Inc. 11,794,222 5.30 2,272,034 3/31/21
Gilead Sciences Inc 11,111,111 5.00 11,111,111 4/23/21
Oracle Investment Management, Inc. 9,373,582 4.21 -2,478,790 3/31/21
Cormorant Asset Management, LP 7,750,000 3.48 750,000 3/31/21
Invus Public Equities Advisors, LLC 6,000,000 2.70 -900,000 3/31/21
Millennium Management LLC 4,087,374 1.84 -306,224 3/31/21
Boxer Capital, L.L.C. 4,000,000 1.80 -- 3/31/21
Sofinnova Investments, Inc 3,478,201 1.56 3,478,201 3/31/21
Geode Capital Management, L.L.C. 2,803,350 1.26 345,755 3/31/21
Point72 Asset Management, L.P. 2,633,800 1.18 2,633,800 3/31/21
First Manhattan Company 2,376,393 1.07 100 3/31/21
Kelley (Brad M) 1,591,039 0.72 -- 4/23/21
Northern Trust Investments, Inc. 1,516,414 0.68 -56,165 3/31/21
Armen (Garo H Ph.D.) 1,433,180 0.64 3,670 6/4/21
D. E. Shaw & Co., L.P. 1,242,269 0.56 -34,998 3/31/21
BlackRock Financial Management, Inc. 1,179,987 0.53 -78,705 3/31/21
Buell (Jennifer) 1,092,327 0.49 1,056,671 4/23/21
Charles Schwab Investment Management, Inc. 1,056,929 0.48 20,053 3/31/21
Nuveen LLC 901,593 0.41 354,851 3/31/21
Goldman Sachs & Company, Inc. 820,257 0.37 180,675 3/31/21
Wells Fargo Advisors 808,006 0.36 -21,758 3/31/21
Citi Investment Research (US) 807,285 0.36 769,922 3/31/21
PanAgora Asset Management Inc. 738,619 0.33 11,807 3/31/21
Ikarian Capital LLC 678,843 0.31 -271,157 3/31/21
Rafferty Asset Management LLC 651,498 0.29 542,399 3/31/21
BlackRock Investment Management, LLC 605,020 0.27 -77,670 3/31/21
Renaissance Technologies LLC 590,215 0.27 -173,300 3/31/21
Los Angeles Capital Management And Equity Research, Inc. 553,744 0.25 -103,215 3/31/21
CAPTRUST Financial Advisors 531,992 0.24 20,000 3/31/21
Susquehanna International Group, LLP 421,953 0.19 125,205 3/31/21
BNY Mellon Asset Management 421,001 0.19 -11,812 3/31/21
Two Sigma Investments, LP 371,724 0.17 -973,452 3/31/21
Schweizerische Nationalbank 325,900 0.15 14,800 3/31/21
UBS Financial Services, Inc. 313,644 0.14 302,396 3/31/21
Hightower Advisors, LLC 308,596 0.14 117,121 3/31/21
California Public Employees' Retirement System 308,500 0.14 -- 3/31/21
Russell Investments Trust Company 307,431 0.14 -39,626 3/31/21
Saling Wealth Advisors 306,003 0.14 10,000 3/31/21
Jane Street Capital, L.L.C. 304,697 0.14 262,305 3/31/21
SEI Investments Management Corporation 281,998 0.13 146,378 4/30/21
Morgan Stanley Smith Barney LLC 271,362 0.12 24,937 3/31/21

* Insider values reflect direct beneficial ownership.

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