Institutional Ownership

Institutional Ownership

Top Holders

Holder Shares Held % O/S Share Change Filing Date
State Street Global Advisors (US) 23,243,261 8.21 5,484,637 6/30/22
Deep Track Capital LP 22,241,417 7.85 8,242,926 6/30/22
The Vanguard Group, Inc. 21,177,555 7.48 2,775,146 6/30/22
BlackRock Institutional Trust Company, N.A. 16,851,603 5.95 2,081,007 6/30/22
Incyte Corp 12,070,195 4.26 -1,992,032 12/31/21
Gilead Sciences Inc 11,111,111 3.92 -- 12/31/21
Oracle Investment Management, Inc. 4,656,132 1.64 -4,050,000 6/30/22
Geode Capital Management, L.L.C. 4,435,167 1.57 581,350 6/30/22
Renaissance Technologies LLC 3,394,615 1.20 -1,528,100 6/30/22
Nuveen LLC 3,005,549 1.06 437,867 6/30/22
Invus Public Equities Advisors, LLC 3,000,000 1.06 -2,500,000 6/30/22
Millennium Management LLC 2,562,464 0.90 -3,169,562 6/30/22
Goldman Sachs & Company, Inc. 2,321,116 0.82 1,018,049 6/30/22
D. E. Shaw & Co., L.P. 2,186,003 0.77 -822,667 6/30/22
Northern Trust Investments, Inc. 2,174,947 0.77 232,302 6/30/22
Morgan Stanley & Co. LLC 2,050,444 0.72 832,648 6/30/22
BlackRock Financial Management, Inc. 1,946,409 0.69 36,269 6/30/22
Charles Schwab Investment Management, Inc. 1,821,054 0.64 128,710 6/30/22
Armen (Garo H.) 1,712,756 0.60 -- 6/17/22
Kelley (Brad M) 1,591,039 0.56 -- 6/17/22
RTW Investments L.P. 1,583,822 0.56 -1,998,659 6/30/22
Wells Fargo Advisors 1,377,942 0.49 334,284 6/30/22
Jess S. Morgan & Company, Inc 1,318,430 0.47 39,850 6/30/22
Acadian Asset Management LLC 1,247,775 0.44 1,247,775 6/30/22
AQR Capital Management, LLC 1,156,812 0.41 635,794 6/30/22
Citi Investment Research (US) 1,009,636 0.36 813,478 6/30/22
Rafferty Asset Management LLC 984,163 0.35 -183,102 6/30/22
Sofinnova Investments, Inc 952,742 0.34 952,742 6/30/22
BlackRock Asset Management Ireland Limited 912,135 0.32 788,031 6/30/22
Bridgeway Capital Management, LLC 876,300 0.31 876,300 6/30/22
BlackRock Advisors (UK) Limited 868,995 0.31 -65,424 8/31/22
Los Angeles Capital Management And Equity Research, Inc. 825,751 0.29 758,363 6/30/22
BlackRock Investment Management, LLC 823,380 0.29 154,421 6/30/22
Point72 Asset Management, L.P. 802,600 0.28 802,600 6/30/22
UBS O'Connor LLC 697,892 0.25 263,892 6/30/22
BNY Mellon Asset Management 647,500 0.23 146,056 6/30/22
Susquehanna International Group, LLP 616,264 0.22 -550,852 6/30/22
CAPTRUST Financial Advisors 613,692 0.22 65,846 6/30/22
Saling Wealth Advisors 610,265 0.22 59,000 6/30/22
SELECTRA Management Company S.A. 580,000 0.20 580,000 6/30/21
Schweizerische Nationalbank 544,400 0.19 58,600 6/30/22
Putnam Investment Management, L.L.C. 533,050 0.19 -6,630 6/30/22
Wellington Management Company, LLP 525,157 0.19 -- 6/30/22
Key Client Fiduciary Advisors, LLC 502,475 0.18 77,790 6/30/22
Hightower Advisors, LLC 435,563 0.15 68,592 6/30/22

* Insider values reflect direct beneficial ownership.

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