Institutional Ownership
Top Holders
| Holder | Shares Held | % O/S | Share Change | Filing Date |
|---|---|---|---|---|
| Incyte Corp | 14,062,227 | 7.40 | -2,910,741 | 12/31/20 |
| RTW Investments L.P. | 12,864,677 | 6.77 | -- | 12/31/20 |
| BlackRock Institutional Trust Company, N.A. | 12,053,187 | 6.34 | 959,769 | 12/31/20 |
| Oracle Investment Management, Inc. | 11,852,372 | 6.23 | -1,282,528 | 12/31/20 |
| State Street Global Advisors (US) | 10,300,531 | 5.42 | 3,575,293 | 12/31/20 |
| The Vanguard Group, Inc. | 9,522,188 | 5.01 | 974,276 | 12/31/20 |
| Cormorant Asset Management, LP | 7,000,000 | 3.68 | -1,500,000 | 12/31/20 |
| Invus Public Equities Advisors, LLC | 6,900,000 | 3.63 | -- | 12/31/20 |
| Millennium Management LLC | 4,393,598 | 2.31 | 1,999,799 | 12/31/20 |
| Boxer Capital, L.L.C. | 4,000,000 | 2.10 | -- | 12/31/20 |
| Geode Capital Management, L.L.C. | 2,457,595 | 1.29 | 212,817 | 12/31/20 |
| First Manhattan Company | 2,376,293 | 1.25 | 985,193 | 12/31/20 |
| Kelley (Brad M) | 1,591,039 | 0.84 | -- | 4/24/20 |
| Northern Trust Investments, Inc. | 1,572,579 | 0.83 | -29,806 | 12/31/20 |
| Two Sigma Investments, LP | 1,345,176 | 0.71 | 393,809 | 12/31/20 |
| D. E. Shaw & Co., L.P. | 1,277,267 | 0.67 | 1,010,384 | 12/31/20 |
| BlackRock Financial Management, Inc. | 1,258,692 | 0.66 | 50,511 | 12/31/20 |
| Charles Schwab Investment Management, Inc. | 1,036,876 | 0.55 | -18,053 | 12/31/20 |
| Ikarian Capital LLC | 950,000 | 0.50 | -- | 12/31/20 |
| Wells Fargo Advisors | 829,764 | 0.44 | -34,138 | 12/31/20 |
| Renaissance Technologies LLC | 763,515 | 0.40 | 592,795 | 12/31/20 |
| Armen (Garo H Ph.D.) | 746,568 | 0.36 | 140,423 | 4/9/21 |
| PanAgora Asset Management Inc. | 726,812 | 0.38 | 6,941 | 12/31/20 |
| BlackRock Investment Management, LLC | 682,690 | 0.36 | -13,570 | 12/31/20 |
| Los Angeles Capital Management And Equity Research, Inc. | 656,959 | 0.35 | 286,075 | 12/31/20 |
| Goldman Sachs & Company, Inc. | 639,582 | 0.34 | 16,974 | 12/31/20 |
| Nuveen LLC | 546,742 | 0.29 | -17,277 | 12/31/20 |
| CAPTRUST Financial Advisors | 511,992 | 0.27 | 15,580 | 12/31/20 |
| BNY Mellon Asset Management | 432,813 | 0.23 | 8,816 | 12/31/20 |
| Morgan Stanley & Co. LLC | 359,320 | 0.19 | 301,570 | 12/31/20 |
| SEI Investments Management Corporation | 355,458 | 0.17 | 355,458 | 3/31/21 |
| Russell Investments Trust Company | 347,057 | 0.18 | 201,611 | 12/31/20 |
| BlackRock Investment Management (UK) Ltd. | 318,419 | 0.17 | -- | 12/31/20 |
| Schweizerische Nationalbank | 311,100 | 0.16 | 22,500 | 12/31/20 |
| California Public Employees' Retirement System | 308,500 | 0.16 | -34,885 | 12/31/20 |
| Susquehanna International Group, LLP | 296,748 | 0.16 | 87,635 | 12/31/20 |
| Saling Wealth Advisors | 296,003 | 0.16 | -- | 12/31/20 |
| PDT Partners, LLC | 253,600 | 0.13 | -- | 12/31/20 |
| Morgan Stanley Smith Barney LLC | 246,425 | 0.13 | 26,375 | 12/31/20 |
| Squarepoint Capital LLP | 241,122 | 0.13 | 98,808 | 12/31/20 |
| California State Teachers Retirement System | 237,847 | 0.13 | 8,253 | 12/31/20 |
| Credit Suisse Securities (USA) LLC | 233,620 | 0.12 | 82,235 | 12/31/20 |
| State of Wisconsin Investment Board | 231,200 | 0.12 | -70,500 | 12/31/20 |
| Principal Global Investors (Equity) | 222,576 | 0.12 | -40,452 | 12/31/20 |
| Verition Fund Management LLC | 211,755 | 0.11 | -70,440 | 12/31/20 |
* Insider values reflect direct beneficial ownership.
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